# @science on Instagram

- **Type:** Image
- **Original URL:** https://www.instagram.com/p/DMi4mXSy9DM
- **Gondola URL:** https://gondola.cc/posts/32741621-science-instagram
- **Thumbnail:** https://img.gondola.cc/tr:w-,h-,fo-auto/postThumbnails/a2bcceb278.jpg
- **Posted:** 2025-07-25T21:00:29.000+00:00
- **Account Owner:** Science 🧬 (@science) — https://gondola.cc/science

## Caption

🧫 Promoting pyroptosis—an inflammatory form of programmed cell death—has become a promising treatment strategy for cancer. In research published in The FASEB Journal, investigators purified a long-chain sugar molecule, or exopolysaccharide, from deep-sea bacteria and demonstrated that it triggers pyroptosis to inhibit tumor growth. ⁠
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The compound, called EPS3.9, consists of mannose and glucose and is produced by the Spongiibacter nanhainus CSC3.9 bacterial strain and other members of the genus Spongiibacter. ⁠
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Mechanistic analyses showed that EPS3.9 can directly target five membrane phospholipid molecules and exert tumor toxicity by stimulating pyroptosis in human leukemia cells. EPS3.9 also had significant anti-tumor effects in mice with liver cancer and activated anti-tumor immune responses. ⁠
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"Our work not only provides a theoretical basis for developing more carbohydrate-based drugs but also highlights the importance of exploring marine microbial resources," said corresponding author Chaomin Sun, Ph.D., of the Chinese Academy of Sciences. ⁠
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#science #bacteria #deepsea #treatment #cells #biology

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## Tags

treatment, bacteria, cells, science, deepsea, biology

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