# @2020glance on Instagram

- **Type:** Image
- **Original URL:** https://www.instagram.com/p/C-dLdSuTKGH
- **Gondola URL:** https://gondola.cc/posts/37443647-2020glance-instagram
- **Thumbnail:** https://img.gondola.cc/tr:w-,h-,fo-auto/postThumbnails/5218eee668.jpg
- **Posted:** 2024-08-09T16:30:03.000+00:00
- **Account Owner:** Glance (@2020glance) — https://gondola.cc/2020glance

## Caption

In a recent study published in Transitional Vision Science and Technology, researchers investigated the causal effects of physical activity (PA) on the risk of developing senile cataracts (SC).

Give me some background first.
Cataracts are one of the most common causes of vision loss in older individuals, affecting an estimated 95 million globally.

Symptoms can include:

Cloudy or blurry vision
Colors appearing faded
Trouble seeing at night
Lamps, sunlight, or headlights appearing too bright
Seeing a halo around lights
Seeing double vision

Needing to change the prescription of glasses or contacts often
In relation to this research: SC—also referred to as age-related cataracts—commonly occurs due to aging.

Now, talk about the study.
Investigators utilized a bidirectional two-sample Mendelian randomization (MR) approach for their analysis.

Several methods were used in their analyses, including:

Primary analysis
Inverse variance weighted method
Secondary analyses
MR-Egger regression
MR-PRESSO
Cochran's Q statistic

Note: Causal estimates were presented as odds ratios (ORs) with 95% confidence intervals (CIs).

What data was used in the study?
Investigators utilized PA summary statistics from a genomewide association study (GWAS) within the United Kingdom (UK) Biobank cohort.

The study involved an estimated 400,000 individuals aged 40 to 69.

A second GWAS study was also mentioned that involved 377,234 individuals of European descent.

Further: The data source for SC was obtained from a dataset on FinnGen, which included 406,781 individuals of European ancestry comprising:

65,235 cases
341,546 controls

Learn more at the link in bio.
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## Tags

optometrist, vision, premed, optometrynews, cornea, nurse, retinopathy, ophthalmology, healthy, contactlenses, medstudent, contacts, womeninmedicine, glaucoma, scrublife, physiciansassistant, optometry, ophthalmologist, residency, dryeyes, surgeon, retina, medicine, keratoconus, eye, glasses, optometrystudent

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