# @mackinprof on Instagram

- **Type:** Image
- **Original URL:** https://www.instagram.com/p/DJO9WQFxW60
- **Gondola URL:** https://gondola.cc/posts/59739264-mackinprof-instagram
- **Thumbnail:** https://img.gondola.cc/tr:w-,h-,fo-auto/postThumbnails/5913192f89.jpg
- **Posted:** 2025-05-04T13:42:40.000+00:00
- **Account Owner:** Stuart Phillips (@mackinprof) — https://gondola.cc/mackinprof

## Caption

Tirzepatide: Preserving Muscle Quality in Type 2 Diabetes

🔥 Big weight loss, small muscle loss 🔥
In the 52-week SURPASS-3 MRI substudy, adults with T2D on tirzepatide lost ~10% of body weight—but thigh muscle volume only fell by ~0.64 L (~6%), matching what you’d expect from ‘normal’ weight loss alone, not an accelerated muscle drain.

💪 Muscle quality actually improved 💪
The magic? Muscle fat infiltration dropped by ~0.36 pp—greater than population-based estimates (≈+0.06 pp). In other words, patients' muscles got leaner and healthier.

🏋️‍♀️ Put a pinch on protein, but… 🥛
Yes, higher protein intake can help preserve lean mass during energy deficits, but let’s be real: resistance training is the undisputed #1 driver to stave off muscle loss. Protein is a very distant #2 in its impact.

📈 What’s next?
Imagine pairing tirzepatide with a structured RT program—could we boost muscle retention and strength (what about bone) even more? We’re still waiting on those data, but the hypothesis is compelling. #staytuned

#Tirzepatide #GLP1RA #MuscleQuality #ResistanceTraining #ProteinPower #BodyComposition #DiabetesCare #SarcopeniaPrevention #ExerciseScience #HealthTec #GLP-1 #Muscle #MuscleQuality #MuscleMass #Weightloss #Health

## Stats

- **Views:** 0
- **Likes:** 666
- **Shares:** 0
- **Comments:** 35

## Tags

staytuned, bodycomposition, diabetescare, resistancetraining, muscle, exercisescience, musclequality, tirzepatide, glp, 2, proteinpower, sarcopeniaprevention, healthtec, glp1ra, musclemass, 1, weightloss, health

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