# @mackinprof on Instagram

- **Type:** Image
- **Original URL:** https://www.instagram.com/p/DKCRmjQKL8P
- **Gondola URL:** https://gondola.cc/posts/59739665-mackinprof-instagram
- **Thumbnail:** https://img.gondola.cc/tr:w-,h-,fo-auto/postThumbnails/fd62037343.jpg
- **Posted:** 2025-05-24T12:00:56.000+00:00
- **Account Owner:** Stuart Phillips (@mackinprof) — https://gondola.cc/mackinprof

## Caption

Weight loss in perimenopause: the laws of physics still work!

Hormonal shifts aren’t destiny—energy balance rules!!

• Macdonald et al. (2003)
1,064 women (45–54 y) followed for 6.3 ± 0.6 y. ↓ Energy expenditure explained most weight gain; dietary calcium and HRT had no effect.
Int J Obes Relat Metab Disord. 2003;27(6):669–676. PMID: 12833110; DOI: 10.1038/sj.ijo.0802283

• Williams et al. (2014)
“40-Something RCT”: 12-mo trial in late pre-/early perimenopausal women (mean 47.3 y; BMI 25.1 kg/m²). Five MI consultations vs self-directed materials—The MI (motivational interviewing) group lost ~2.6 kg and lowered diastolic BP.
Nutr Diabetes. 2014;4:e116. PMID: 24799163; DOI: 10.1038/nutd.2014.12

• Hao et al. (2022)
78 perimenopausal women randomized to (A) education only, (B) diet, or (C) diet + supervised resistance exercise for 3 mo. Groups B & C saw ↓ BMI, trunk fat, and waist circumference; group C also ↑ lean mass.
Front Nutr. 2022;8:752500. PMID: 35155511; DOI: 10.3389/fnut.2021.752500

• Thomson et al. (2020)
Systematic review/meta-analysis of 10 dietary ± exercise interventions (n=791) found no differences in weight, fat-mass, or lean-mass loss between pre- and postmenopausal women—suggesting similar responses.
Menopause. 2020;28(3):337–346. PMID: 33350666; DOI: 10.1097/GME.0000000000001684

Takeaway: Even in perimenopause, energy intake vs. expenditure is king. Structured diet and exercise—especially with resistance training and behaviour-change support—work to shed fat and preserve lean mass.

```
#Perimenopause
#WeightLossJourney
#EnergyBalance
#WomenInMidlife
#HealthyAging
#HormoneHealth
#FitOver40
#NutritionMatters
#ResistanceTraining
#StrengthTraining
#MindfulEating
#MetabolicHealth
#BehaviorChange
#LifestyleMedicine
#WellnessForWomen
#FatLossTips
#LeanMuscle
#MidlifeFitness
#ExerciseAndDiet
#ScienceBacked
```

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## Tags

weightlossjourney, wellnessforwomen, resistancetraining, leanmuscle, hormonehealth, energybalance, sciencebacked, mindfuleating, womeninmidlife, healthyaging, fitover40, metabolichealth, midlifefitness, lifestylemedicine, exerciseanddiet, strengthtraining, behaviorchange, perimenopause, nutritionmatters, fatlosstips

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