# @nickpappasmd on Instagram

- **Type:** Video
- **Original URL:** https://www.instagram.com/p/DWxULG6DTHq
- **Gondola URL:** https://gondola.cc/posts/62527685-nickpappasmd-instagram
- **Thumbnail:** https://img.gondola.cc/tr:w-,h-,fo-auto/postThumbnails/be4ca634dd.jpg
- **Posted:** 2026-04-06T00:45:28.000+00:00
- **Account Owner:** Nick Pappas, MD (@nickpappasmd) — https://gondola.cc/nickpappasmd

## Caption

✅ Turmeric (the active component of which is curcumin) is a spice commonly used in Indian cuisine with known anti-inflammatory properties.

👇 Turmeric reduces inflammatory markers like IL-6 & TNF-alpha.  It also inhibits the COX-2 enzyme (similar to NSAIDs).

😷 Regarding detoxing the body, there are some animal studies showing it may help enhance liver function, but I did not find any quality human studies confirming that claim.

🧠 As for reducing the risk of Alzheimer’s Disease, there are basic science studies showing it may help your body remove the amyloid deposits found in Alzheimer’s, but I did not find any quality clinical human studies.

✅ The recommended dose is 500 to 2000 mg per day.  In the studies I’ve looked at it, the dose taken is usually around 1000-1500 mg.

👉 Absorption is an issue with turmeric, so some people combine it with black pepper (piperine), which can significantly increase the absorption, sometimes by upto 2000%. When that is the case, it might be easier to overdose.  Use of a liposomal delivery system can also increase absorption.

💊 She was taking 2500 mg per day.  This is definitely too much, and there are case reports of people having liver damage from high doses of turmeric, especially when combined with the black pepper.

👴🏻 In my experience, turmeric does decrease pain from arthritis. 📚 In fact, there is a randomized controlled trial (PMID: 24672232) that does show turmeric is comparable in pain relief to ibuprofen with fewer side effects.  There is also a recent supporting meta-analysis (PMID: 39712249).

🚨 The most common side effects generally are G.I. related like nausea or upset stomach, similar to NSAIDs.  Like NSAIDs, turmeric can also increase your bleeding risk.

👉 This case is a good example of why you always need to be careful with supplements, as they can have side effects just like any medication.  Always be sure to check with your doctor before studying any new supplement.

#thepitt #turmeric #supplements

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## Tags

supplements, thepitt, turmeric

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