# @wealthinsides on Instagram

- **Type:** Video
- **Original URL:** https://www.instagram.com/p/DdvYWdNSU3v
- **Gondola URL:** https://gondola.cc/posts/70927487-wealthinsides-instagram
- **Thumbnail:** https://img.gondola.cc/tr:w-,h-,fo-auto/postThumbnails/ecaff64fd9.jpg
- **Posted:** 2026-09-26T06:24:26.000+00:00
- **Account Owner:** WEALTH INSIDES™ (@wealthinsides) — https://gondola.cc/wealthinsides

## Caption

Scientists in Japan have achieved a remarkable step in chromosome-level gene editing. 🧬

Researchers at Mie University used CRISPR-Cas9 to target the extra copy of chromosome 21 found in cells with Down syndrome, also known as trisomy 21.

Normally, human cells have two copies of chromosome 21. In Down syndrome, there are three. The Japanese research team developed a technique designed to distinguish the extra chromosome from the two copies that should remain, then used CRISPR to make multiple targeted cuts so the extra chromosome could be eliminated.

In their experiments, the researchers successfully removed the targeted extra chromosome from laboratory-grown human trisomy 21 cells, including induced pluripotent stem cells and fibroblasts. The reported chromosome-loss efficiency reached up to about 37.5% under certain experimental conditions. The edited cells also showed changes in gene expression and cellular characteristics toward those seen after chromosome correction. 🧬🔬

But there’s an important catch:

This does NOT mean that Down syndrome has been cured.

The experiment was performed on cells in the laboratory — not on people. The researchers themselves describe the work as a proof of concept, and the technique still faces major challenges, including editing accuracy, unintended chromosome changes, delivery into the right cells, safety, and whether the approach can work reliably in living organisms.

That distinction matters because removing an entire chromosome is dramatically more complicated than editing a single gene.

Still, the significance of the research is that scientists have demonstrated that it is possible, under controlled laboratory conditions, to selectively target and eliminate an extra human chromosome using CRISPR-based editing.

Source: Mie University / PNAS Nexus, 2025

(All rights and credits belong to their respective owners. This content is shared for educational and entertainment purposes only.)

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#technology #japanesetechnology #innovation #crispr #medicalscience

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## Tags

japanesetechnology, crispr, innovation, technology, medicalscience

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