# @thecrnaclub on Instagram

- **Type:** Image
- **Original URL:** https://www.instagram.com/p/CvBJMongWMN
- **Gondola URL:** https://gondola.cc/posts/77095966-thecrnaclub-instagram
- **Thumbnail:** https://img.gondola.cc/tr:w-,h-,fo-auto/postThumbnails/e2282bd292.jpg
- **Posted:** 2023-07-22T23:20:38.000+00:00
- **Account Owner:** Community for aspiring CRNAs (@thecrnaclub) — https://gondola.cc/thecrnaclub

## Caption

We about to get nerdy up in here. CRNA_Scientist just did a post about the neuromuscular junction, and we're about to discuss the synaptic cleft. ⁠
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Both are important to understand, because so much of what we do as ICU nurses and CRNAs has effects here. ⁠
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So what is the synaptic cleft exactly? ⁠
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👉 The synaptic cleft is a connection between two nerve cells. It's a tiny gap that separates the sending end of one neuron from the receiving end of the next. When an electrical signal reaches the sending neuron, it releases chemical messengers called neurotransmitters into this gap (like norepinephrine!). These neurotransmitters then bind to receptors on the receiving neuron (like alpha and beta), enabling the transmission of information between neurons in the nervous system. This causes a cascade of events like: ⁠
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👉 raise the BP ⁠
👉 increase contractility ⁠
👉 cause smooth muscle relaxation ⁠
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So, as you can see, understanding what happens here is critical to understanding the mechanism of action of our drugs. Which is what we'll keep working through in this 3 part series.
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Save this for later! ⁠
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#icunurse #icu #icunurselife #nursesofig #diversitycrna #anesthesiologylife #anesthesialife #ccrn #criticalcaremedicine #sicu #intubation #travelrn #travelnurse #icurn #rnlife #crnaschool #crna #anesthesiaschool  #nurseanesthesia #nurseanesthesiology #nurseanesthetist #nurseanesthesiologist #nurselife #nurses #nursing #nursesofinstagram #nursepractitioner #nursesrock

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## Tags

nurselife, travelrn, anesthesiaschool, crnaschool, anesthesiologylife, rnlife, nursesofinstagram, diversitycrna, intubation, nurses, nurseanesthesia, nurseanesthesiology, icunurselife, icunurse, sicu, nursing, nursepractitioner, crna, anesthesialife, nurseanesthesiologist, icurn, criticalcaremedicine, travelnurse, ccrn, nursesrock, nursesofig, nurseanesthetist, icu

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