Angiogenesis is the creation of new blood vessels. Tumors use it to grow. Many of our modern front-line therapies against cancer incorporate anti-angiogenesis strategies, opposing the creation of blood vessels. In other words, fighting cancer by cutting off tumor supply lines.
Without a blood supply, some cancers are only able to grow to be about the size of the tip of a ballpoint pen, then tumor growth stalls. Autopsy studies show that virtually everyone has tiny tumors in them by age 70. “Cancer-without-disease” can, therefore, be considered the normal state during aging.
Tumors release angiogenic factors, chemicals that cause new blood vessels to sprout toward the cancer. Once a blood vessel reaches the tumor and attaches, it’s off to the races and the tumor can take off like wildfire. By starving cancer of its blood supply, chemotherapy that blocks this process can sometimes cause tumors to shrink. But, ideally, we wouldn’t have to wait until such a late stage to nip them in the ...