A new miniature microscope captures real-time voltage signals in awake animals, which could expand our understanding of neural activity and lead to new treatments for neurological disorders.
Here, Emily Gibson from the University of Colorado Anschutz Medical Campus explains how the microscope works.
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Paper: C. A. Saladrigas, F. Speed, A. Teel, M. Zohrabi, E. J. Miscles, G. L. Futia, L. V. Baker, Y. Zhang, I. Kymissis, V. M. Bright, C. G. Welle, D. Restrepo, J. T. Gopinath, E. A. Gibson, “Miniaturized widefield microscope for high speed in vivo voltage imaging,” Biomed. Opt. Express, 17, 1-11 (2025).
DOI: 10.1364/BOE.576516