Both creams are wildly popular; Crème de La Mer has had a following of skin-care devotees since its debut in 1965. And Avène Cicalfate+ Restorative Protective Cream is the number one derm-prescribed cream in Europe, with a bottle sold every five seconds around the world. While ingredient lists are comparable on paper, the actual application and experience is another thing entirely. Read what happened when one writer made the swap at the link in our bio! #iamwellandgood