England face significant injury setbacks ahead of the Six Nations with Jamie George set to miss their opening fixture against Ireland 🏴󠁧󠁢󠁥󠁮󠁧󠁿 Hooker George has been replaced by Maro Itoje as captain, suffered a hamstring injury in Saracens’ Champions Cup match. Alex Mitchell has also pulled out but will travel for rehab. Jack van Poortvliet, Alex Coles and Alex Dombrandt are also injured and likely to miss the opener. Take a look at our earlier post to see their replacements. #GBR5 #EnglandRugby #SixNations2025