Will your 12VHPWR cable work with 12V-2x6? The answer is yes, there is no difference between them. The changes in revising the 12VHPWR connector and renaming it to the 12V-2x6 were only made to the connector on the graphics card. Of course, you need to be aware of the power consumption of the video card, and make sure that both the cable and the power supply are capable of delivering the minimum power required through the cable. We are #NextGenReady, are you?