How could a single psychedelic treatment cause lasting change? Joshua Siegel, MD, PhD, is on a mission to find out. A leading researcher on neuroimaging and neuropsychopharmacology at NYU Langone’s Center for Psychedelic Medicine, Dr. Siegel unpacks how psilocybin may spark neuroplasticity and reshape the depressed brain. He also gives us an inside look at the race to develop non-hallucinogenic psychedelic analogs—compounds that offer the benefits without the “trips.” Dr. Siegel is an assistant professor at the NYU Grossman School of Medicine. Topics Covered (AUDIO-ONLY) 00:00 Introduction 00:15 Dr. Siegel's Current Work 01:01 Past Research and Human Psilocybin Imaging Study 02:39 Understanding Brain Changes and Biomarkers 06:13 Mechanisms of Action and Plasticity 12:51 Surprising Findings and Context Dependence 16:34 Challenges and Future Directions in Psychedelic Research 20:46 Advanced Imaging and Personalized Treatment Plans 24:15 Setbacks and Lessons in Psychedelic Medicine 28:40...