Brunkow, Ramsdell and Sakaguchi win 2025 Nobel medicine prize ⁣ ⁣ “The body’s powerful immune system must be regulated, or it may attack our own organs.” ⁣ ⁣ Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi have been awarded this year’s Nobel Prize Medicine for their discoveries concerning peripheral immune tolerance that prevents the ⁣ immune system from harming the body.⁣ ⁣ "Their discoveries have laid the foundation for a new field of research and spurred the development of new treatments, for example for cancer and autoimmune diseases," the prize-awarding body added in a statement.⁣ ⁣ The laureates identified so-called regulatory T cells, which act as the immune system's security guards that keep immune cells from attacking our own body, it said.⁣ ⁣ Brunkow is senior programme manager at the Institute for Systems Biology in Seattle, while Ramsdell is scientific adviser at Sonoma Biotherapeutics in San Francisco, which he co-founded. Sakaguchi is a professor at Osaka University i...