In October 2025, A
@nature.portfolio commentary by
#StanDOM's Rebecca Handler, Sonali Sharma and Tina Hernandez-Boussard was published on "The Fragile Intelligence of GPT-5 in Medicine."
The authors unpack how OpenAI's latest large language model shows meaningful safety gains — but also persistent risks that matter deeply in healthcare.
Their piece explores key vulnerabilities including:
- Confident hallucinations that can sound persuasive
- Dual-use and biosecurity risks when safeguards are bypassed
- The illusion of reasoning versus true understanding
Their central message: GPT-5 largely remains a next-word prediction system, not a reasoning engine — and in medicine, that distinction is critical.
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#25MomentsOf2025 #AIInMedicine #AIHealthcareSafety