Charles Marmar, MD, Chair of Psychiatry at NYU Grossman School of Medicine, discusses how precision psychiatry is reshaping the way clinicians and researchers think about diagnosis, treatment selection, and the underlying biology of psychiatric disorders. This conversation is a overview of where the field stands today—including emerging molecular markers, biologically informed subtypes, and new translational approaches inspired by oncology and other precision-based specialties. Dr. Marmar outlines current work on: • Molecular and genomic signatures that may distinguish patient subtypes • Clinical trials examining targeted treatments for alcohol use disorder • The development of proxy “brain biopsy” methods such as exosomal analyses and iPSC-derived organoids • How converging biological data could eventually support more individualized treatment planning This discussion reflects ongoing efforts at NYU Langone Health to move psychiatry toward a more mechanism-based, biologically ...