Drone footage showed a crater in the ground and heavily damaged houses in central Israel, after strikes presumed to be from Iran.
The Magen David Adom ambulance service said it has received no reports of injuries following the latest attacks, according to local reports.
The Iran war started with joint US and Israeli air strikes two weeks ago, leading to around 2,000 people killed and throwing global energy markets and transport into chaos.
The conflict has spread across the Middle East and prompted plans for a record release of strategic oil reserves to dampen one of the worst fuel shocks since the 1970s.
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