Tirzepatide: Preserving Muscle Quality in Type 2 Diabetes 🔥 Big weight loss, small muscle loss 🔥 In the 52-week SURPASS-3 MRI substudy, adults with T2D on tirzepatide lost ~10% of body weight—but thigh muscle volume only fell by ~0.64 L (~6%), matching what you’d expect from ‘normal’ weight loss alone, not an accelerated muscle drain. 💪 Muscle quality actually improved 💪 The magic? Muscle fat infiltration dropped by ~0.36 pp—greater than population-based estimates (≈+0.06 pp). In other words, patients' muscles got leaner and healthier. 🏋️‍♀️ Put a pinch on protein, but… 🥛 Yes, higher protein intake can help preserve lean mass during energy deficits, but let’s be real: resistance training is the undisputed #1 driver to stave off muscle loss. Protein is a very distant #2 in its impact. 📈 What’s next? Imagine pairing tirzepatide with a structured RT program—could we boost muscle retention and strength (what about bone) even more? We’re still waiting on those data, but the hypot...