💡 Anabolic Resistance & Aging As we age, skeletal muscle becomes less responsive to protein (“anabolic resistance”), meaning higher protein or leucine doses are needed to kick-start muscle protein synthesis (MPS). However, healthy older women (mean age 69 ± 1 y) remain remarkably protein-sensitive—both acutely (hourly) and chronically (daily). ________________________________________ 🔬 Key Findings in Older Women (65–75 y) 1. Acute MyoPS Response o After fasted-state unilateral resistance exercise, consuming a 15 g protein drink with ~4.2 g leucine increased myofibrillar MPS by 87% in the exercised leg—vs. 30% with a lower-leucine beverage (PMID: 29529146). 2. Integrated (Chronic) MyoPS o When integrated into a weight-maintaining diet (1.0 g·kg⁻¹·d⁻¹) over 6 days, twice-daily high-leucine supplementation elevated daily MPS by 17% in exercised muscle and 9% in rested muscle (PMID: 29529146). 3. Leucine “Trigger” vs. Total Protein o A lower-protein (10 g) beverage fortified with 3 g le...