Your doctor isn’t telling you this, but I will.
What you’re experiencing:
“I started HRT progesterone and now I’m bloated, hungry, and gaining weight. My friend is on the same thing and she’s fine. What’s going on?”
What nobody’s explaining:
The SAME hormone works completely differently depending on YOUR metabolic health. And if this is happening to you, you’re not stuck.
Here’s what the research actually shows:
🧬 The Insulin Connection:
Research published in the American Journal of Physiology found that progesterone can inhibit insulin signaling in adipocytes. BUT this effect is dramatically amplified in women with existing insulin resistance.
💡 The Metabolic Context:
A 2020 study in Scientific Reports showed progesterone increases glucose production via the liver ONLY when insulin action is already impaired. In metabolically healthy women? It supports normal glucose regulation.
😴 The Cortisol Trade-Off:
Your body makes cortisol from the same precursors as progesterone. When y...
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