In a medical first, doctors raced to create a bespoke CRISPR gene therapy for a boy born with a deadly genetic disease and delivered it to him a mere six and a half months after birth. “This was a remarkable team effort,” adds Jennifer Doudna, founder of the Innovative Genomics Institute and recipient of the 2020 Nobel Prize in Chemistry for her role in the development of CRISPR gene editing. “The ability to develop an on-demand CRISPR therapy in such a short time opens up a new era for treating previously untreatable genetic diseases.” The CRISPR treatment was administered safely, and the infant is now growing well and thriving, his doctors say. They hope that the treatment will make a liver transplant, which is usually required for survival, unnecessary for him. In this 101 in 101 video, Dr. Petros Giannikopoulos, the Director of the Innovative Genomics Institute Clinical Laboratory at UC Berkeley, explains how a team of researchers and doctors created this first on-demand CRISPR...