Khalil Mack played Ohio State in the season opener of his senior year at Buffalo (August 31, 2013). It was arguably the breakout performance of his college career.
Stats vs. Ohio State:
9.5 tackles
2.5 sacks
1 interception returned 45 yards for a touchdown
Buffalo lost the game 40–20, but Mack left his mark. His 45-yard pick-six in the second quarter cut the deficit to 23–13. 
(espn)