Eyewitness footage shows the Frannçois Rabelais high school in Metz, eastern France, in flames.
Authorities have launched an investigation into the cause of the fire.
The Public Prosecutor said he could neither “confirm nor rule out a link” between the fire and the nationwide high school protests over the past few days.
Protesting students say their school hours are needlessly long, there are too many staff absences and classroom conditions are inadequate.
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